Understanding how distinct cells utilize the same genetic material is the main goal of Sascha Duttke's study. New biological principles, particularly those pertaining to the activation or inactivation of genes and the function of certain regulatory systems, may be discovered as a result of this research.
The Human Genome And The Transcription Factor
Transcription Factors and Human Genome
- The human genome encompasses all the genetic information entailed to create and maintain a human being.
- Transcription factors: proteins that scan DNA for data, and initiate the transcribing process.
- Gene expression can be affected by the positions of transcription factor binding sites.
Study Conducted
- RNA sequencing and other specialist techniques were employed to characterise the transcription factors.
- In addition, binding site locations, relative to the start of transcription for a gene, can be performed even when its transcription factor binding sites are found either upstream or downstream of a gene.
How Genetic Variations Affect You
- More than 4 million genetic variants were analyzed, and their position on DNA impact the process of working with this genetic code.
- By understanding these factors, more disease-associated mutations can be found, which can ultimately benefit the genetic diagnosis and treatment of very severe, so-called monogenic, diseases.
'Spatial Grammar' Concept
- The term 'spatial grammar' refers to the set of rules determining the interaction between transcription factors and their respective binding sites.
- it may clarify evolution and the way more complicated life-elements have kind over period of time.
Month: Current Affairs - November 05, 2024
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