GUT-First Hypothesis for Parkinson Disease

According to recent research, Parkinson's disease (PD) may be caused and exacerbated by issues with the gastrointestinal (GI) system, a theory known as the "gut-first hypothesis." According to a significant research that was published in JAMA Network Open, individuals with upper gastrointestinal tract injury had a 76% increased risk of developing Parkinson's disease.

The Role of the Gut-Brain Axis in Parkinson's Disease

• Gut health and Parkinson … most have constipation before motor symptoms, a gut mottled with abnormalities supporting the idea that these issues are interwoven: evidence linking them together.
• The gut microbiome — the community of different bacteria that live in our intestines — helps regulate immune and metabolic functions. Although PD is associated with a dysbiosis of gut bacteria.
• Diet may be linked to gut health, which in turn, is increasingly thought to play a key role in Parkinson's disease risk (the increasing consumption of ultra-processed food and over-the-counter antibiotics has only been recently studied).
• Study of gut-brain connection can aid diagnosis during early stages and using innovative treatments, such as faecal microbiota transplant.
• Gut-brain connection because of how the stomach and brain talk to each other, with over 90% of serotonin produced in the gut
• Brain diseases such as Alzheimer's have a high correlation with gut health, therefore the gut brain connection is maintained when fiber is consumed.