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CALM-Brain Repository: India’s Breakthrough in Neuropsychiatric Research

NIMHANS–NCBS Develop CALM-Brain Digital Platform for Mental Health Data

Researchers at the Rohini Nilekani Centre for Brain and Mind have developed CALM-Brain, an advanced digital repository designed to study neuropsychiatric disorders. The initiative strengthens India’s capacity for data-driven mental health research.


About CALM-Brain Initiative

CALM-Brain is a first-of-its-kind platform in India that compiles extensive data on brain structure and function across psychiatric conditions. It originated in 2016 under the ADBS programme and is supported by institutions such as National Institute of Mental Health and Neurosciences and National Centre for Biological Sciences, with funding from the Department of Biotechnology and the Pratiksha Trust.


Scope and Data Collection

The repository integrates diverse datasets, including clinical records, neuroimaging scans, behavioural assessments and genetic information. It focuses on five major disorders—addiction, bipolar disorder, dementia, obsessive-compulsive disorder and schizophrenia—allowing a comprehensive and multidisciplinary understanding of brain-related conditions.


Objectives and Research Significance

The platform aims to uncover patterns related to disease onset, progression and biological mechanisms. By providing open access to researchers and clinicians, it promotes collaboration and accelerates advancements in neuroscience. The integration of large-scale datasets enables more accurate and evidence-based research outcomes.


Clinical and Practical Applications

CALM-Brain is expected to enhance diagnostic accuracy and treatment planning for mental illnesses. It supports early detection, monitoring of disease progression and development of personalised therapies. The initiative also contributes to precision medicine by linking biological data with clinical outcomes, improving mental healthcare delivery in India.


Exam-Focused Points

  • Initiative: CALM-Brain (digital brain data repository)

  • Institutions: CBM (NIMHANS + NCBS-TIFR collaboration)

  • Launched under: ADBS programme (2016)

  • Disorders covered: Addiction, Bipolar, Dementia, OCD, Schizophrenia

  • Data types: Clinical, imaging, behavioural, genetic

  • Aim: Research collaboration + precision mental healthcare

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