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Lancet Study Warns HbA1c Testing May Mislead Diabetes Diagnosis in India

Integration of Continuous Glucose Monitoring (CGM)

  • Consideration of alternative biomarkers such as fructosamine

  • This layered diagnostic approach is intended to minimise misclassification and improve patient outcomes.


    Exam-Focused Points

    • HbA1c reflects glycaemic exposure over RBC lifespan

    • Anaemia and haemoglobin disorders can distort HbA1c values

    • G6PD deficiency may lead to falsely low HbA1c readings

    • OGTT remains a gold-standard diagnostic test for diabetes

    • Laboratory standardisation is crucial for biomarker reliability

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