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Lancet Study Questions Reliability of HbA1c Testing for Diabetes Diagnosis in India

  • Consideration of alternative biomarkers like fructosamine

  • This integrated approach aims to reduce misclassification and enhance diagnostic precision.


    Exam-Focused Points

    • HbA1c reflects average glucose over RBC lifespan

    • Anaemia can significantly alter HbA1c readings

    • G6PD deficiency shortens RBC lifespan and lowers HbA1c

    • OGTT remains a gold-standard diagnostic test

    • Laboratory standardisation affects biomarker reliability

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